If it's a PvE necro, the choices are N/Me or N/Mo, as far as i can see. If you're likely to do duo 55hp runs, then N/Me is better, as you can use Arcane Echo & SV and interrupts etc. N/Mo is better for MMs as they can use Heal Area to assist with healing etc.
On the PvP side, there are lots of choices as far as I can see.
You could be an IWAY necro [orders (N/Mo) or Tainted (N/E)]
You could play an SS necro with windborne speed (N/E), although if you're playing SS, then you can have pretty much any second profession.
You could play a Blood Spike necro (N/Mo)...
All in all, lots of choices.
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